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For the programme's success. These are employees who even in their free time motivate their colleagues and their colleagues' families and friends to be tested and counselled. The programme extends not only to the 3, 000 or so employees in Rosslyn, but also, as demanded by AIDS activists, to their family members and in future to the BMW dealership organisation and suppliers. BMW South Africa plays a pioneering role in the Cape. If necessary, BMW South Africa also meets the costs of drugs for family members of up to rand 1, 200 almost euro 150 ; per month; since drug prices have fallen this is sufficient cover. Wolfgang Stadler, President of BMW South Africa, refers with some pride to the success of the programme, which is based on what he calls a "culture of trust". He says around 86 percent of the employees have already undergone voluntary testing, the BMW employees' problem awareness and knowledge are way above the national average and the number of new infections thus well below it. Stadler has no problems admitting that it is not only a company's duty to care for its employees that drives BMW South Africa to fight against HIV AIDS, but also level-headed economic reason. Stadler says the new South Africa is "on the right path" and the location is promising. Of course long absences of employees infected with HIV or suffering from AIDS should be avoided; after all, the Company has paid good money to train them. From this point of view, social commitment is not just a matter of the heart but also of the mind, which is why managers talk of "social investment". Ernst Baumann, BMW Group Board Member for Human Resources, goes one step further. He no longer sees social investment as a soft factor. BMW is not just the most popular company in South Africa because of the quality of its vehicles. "A large part of our success is due to our focus on society, " says.
J00s, H. A., and Johnson, J. L.: Digitalis Intoxication in Infancy and Childhood. Pediatries 20: 866 Nov. ; , 1957. This is a report of 10 instances of digitalis intoxication in 6 infants under 2 years of age, and in 4 children, the oldest being 8, which the authors encountered in their work at the Children's Hospital in Los Angeles. The family physician's prescription was responsible for overdigitalization in the majority of patients, although 1 was an error by the pharmacist in the preparation, and in another case miscalculation of a dose by a nurse was responsible for the poisoning. Vomiting and heart failure are the 2 chief clinical manifestations in these patients. Arrhythmias are a minor presenting symptom. Dehydration is a possible factor in contributing to digitalis poisoning. A great variety of electrocardiographic disturbances was found. The disturbances were commonly super-ventricular arrhythmias or changes in A-V conduction. It is emphasized that congestive heart failure may be a frequent manifestation of digitalis intoxication and cause some confusion in the elucidation of its actual cause when induced by over-digitalization. A plea is made for the use of more standardized products familiar to both physicians and pharmacists. HARVEY.
FREQUENCY: 9% of AIDS patients referred for psychiatric evaluation DIAGNOSIS: Manic episodes and depressive episodes and mixed episodes. Differential includes familial bipolar disorder and AIDS mania no family history, no episodes prior to late stage HIV, co-morbid cognitive impairment. TREATMENT.
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1.8 * 0.3 rig L ; group P 0.002; P 0.002, respectively ; . The rhGH treatment induced similar increase in the mean 24-h GH concentrations in all groups studied mean difference before vs. on rhGH: CpN 1.3 + 0.5; CpP 1.2 + 0.2; controls 0.8 + 0.2 rig L ; . This increase, expressed as percentage change of pretreatment levels, was however, the lowest in the CpN group CpN 39%; CpP 92%; controls 81% ; and statistically significant only in CpP group P 0.01 ; . Although CpP patients had higher 24-h GH values than controls the differences were not significant either before or on rhGH treatment. Subcutaneous administration of 4 IU rhGH at 2000 h ameliorated characteristic bursts of GH during the night. The increment in GH concentrations after rhGH injection the mean of values between 2100 h and 0700 h ; was significant in all groups studied: CpP patients before - 1.8 + 0.7 rig L; after - 5.2 + 0.6 rig L, P 0.001 CpN group before - 4.3 f 0.8 rig L; after - 8.4 + 0.8 rig L, P 0.001 ; and controls before - 1.0 + 0.6 rig L; after - 3.7 f 0.6 rig L, P 0.01 ; . The mean daytime GH level between 0800 h and 2000 h ; became lower on GH treatment in all patients and healthy subjects studied although the differences in comparison to pretreatment levels were not significant CpP group: 1.1 + 0.2 rig L before, 0.6 + 0.2 rig L after; CpN group: 2.4 + 0.4 rig L before, 1.5 + 0.4 rig L after; controls: 1.0 + 0.2 rig L before, 0.5 + 0.2 rig L after ; . C-peptide Fig, 3 ; The mean 24-h C-peptide value was greater in controls than in CpP diabetics before and on rhGH treatment. However, this difference was significant only before treatment 430 f 110 pmol L vs. 880 + 140 pmol L, P 0.04 ; . Recombinant hGH treatment induced an increase in C-peptide values in both groups which was not statistically significant. IGF-I Figs. 4 and 5 ; Mean pretreatment serum IGF-I concentrations were not significantly different between CpN 25.6 + 2.8 nmol L ; , CpP 28.5 f 1.9 nmol L ; patients and controls 29.7 + 0.8 nmol L ; . The net increase in IGF-I concentrations on rhGH treatment was significantly greater in CpP diabetics 15.8 + 3.4 nmol L ; and controls 26.7 f 12.4 nmol L ; than in CpN patients 4.6 k 1.7 nmol L ; CpN vs. CpP - P 0.003; CpN vs. controls - P 0.05 and bleomycin.
Funding Support: This research was supported by grant 031461 from the Robert Wood Johnson Foundation. Acknowledgment: We are grateful for the assistance from the Office of Applied Studies, the Substance Abuse and Mental Health Services Administration, and the US Drug Enforcement Administration, Office of Diversion Control, Drug Operations Section. REFERENCES 1. Institute of Medicine, Committee on Care at the End of Life. In: Field MJ, Cassel CK, eds. ApproachJAMA, April 5, 2000--Vol 283, No. 13 1713.
Focrii ar~nlljsc~s Tlie crucle protein CL' ; contc, nts of tlic. compounds were a s predicted dnd were similar for , 311 tliree treatments Table 1 ; . The maize silages Table 2 ; l i , typicCilCP Ic\, els of 82 to 100 g k g MAFF, lc190 ; . Tlic estimated ME of the silciges in t l tirst 2 y e were below a\, crage ancl the DM content was also below the le\.el recornmended by Wilkinson c, i 171. 1978 ; for optini~rrnyield of nutrients ~ n lot\, le\rels d of effluent production. tlowever, iii experiment 3, the early-maturing \, aricty 12C; 2080 h C ~adhigher DM colite~it dnd aii improved ME which was ' ~ b ~iveragele\, els MAFF, 1990 ; . Although the ensiled crops differed in their maturity 'incl feeding v a l over the three experi~ncntsthis d0c.s not in\.alidatc, comparisons o f , iniin, ll perform'mcc m'jdr \vitlii~l years, ancl between-year ~ o i n not of arc p d r importance in these experiments. t and boniva.
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Figure 4. Quantitative analysis of the activities of six homing endonuclease variants of I-ScaI and PI-SceI. Cells harboring pBar2-PI-SceI-site left three bars ; or pBar2-I-ScaI-site right three bars ; were transformed with the pSupE-nuclease plasmids encoding the six nucleases listed and processed as described in the Materials and Methods. The percentage of surviving colonies on arabinose-containing media relative to the number of colonies arising from an identical number of transformants plated on glucose-containing media is shown for each nuclease. Values reflect the average of three independent trials and standard deviations were 15% of each value reported and bosentan.
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Reference: 1. Maillefert JF, Tonolli-Serabian I, Cherasse A, Demoux AL, Tavernier C, Piroth L. Arthritis following combined vaccine against diphtheria, polyomyelitis, and tetanus toxoid. Clin Exp Rheumatol. 2000; 18 2 ; : 255-6. 2. Pope JE, Stevens A, Howson W, Bell DA. The development of rheumatoid arthritis after recombinant hepatitis B vaccination. J Rheumatol. 1998; 25 9 ; : 1687-93.
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Kimsey PB, Goad ME, Zhao ZB, Brackee G, and Fox JG. Methyl prednisolone acetate modulation of infection and subsequent pulmonary pathology in hamsters exposed to parainfluenza-1 virus Sendai ; . Rev Respir Dis 140: 1704-1711, 1989 and bumetanide.
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